< APIs (Active Pharmaceutical Ingredients)

Anamorelin HCl

Technical Information

  • CAS no.: 861998-00-7

  • Type: API

  • Usage: Supportive treatment for cancer, weight gain

  • Technical description
    Anamorelin Hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.

  • IUPAC name: 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride.

  • Molecular formula: C31H43ClN6O3

  • Molecular Weight: 583.2 g/mol

  • Class: Anamorelin HCl (anamorelin hydrochloride) is pharmacologically classified as a selective agonist of the ghrelin receptor (also known as the growth hormone secretagogue receptor or GHSR).

  • Synonyms: RC-1291, ONO-7643, ST-1291.

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