Daprodustat

CAS no.: 960539-70-2

Type: API

Usage: Anemia in chronic kidney disease

Technical description
Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease. It has a role as an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor, an antiviral agent and an anti-anaemic agent. It is a secondary carboxamide, a N-acylglycine, a member of barbiturates and an oxo monocarboxylic acid.

IUPAC name: 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid.

Molecular formula: C₁₉H₂₇N₃O₆

Molecular Weight: 393.4 g/mol

Class: HIF prolyl hydroxylase inhibitor (HIF-PHI).

Synonyms: GSK1278863 – GSK-1278863 – JESDUVROQ.