Sorafenib Tosylate

CAS no.: 475207-59-1

Type: API

Usage: Various kinase inhibitors

Technical description
Sorafenib Tosylate is the tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.

IUPAC name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid.

Molecular formula: C₂₈H₂₄ClF₃N₄O₆S

Molecular Weight: 637.0 g/mol

Class: Multikinase inhibitor (or tyrosine kinase inhibitor).

Synonyms: BAY 43-9006, BAY 54-9085, BAY 43-9006 tosylate salt.