Zuranolone

CAS no.: 1632051-40-1

Type: API

Usage: Postpartum depression

Technical description
Zuranolone is a 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults. It has a role as an antidepressant, an anticonvulsant and a GABA modulator. It is a nitrile, a member of pyrazoles, a 3-hydroxy steroid and a 20-oxo steroid.

IUPAC name: 1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile.

Molecular formula: C₂₅H₃₅N₃O₂

Molecular Weight: 409.6 g/mol

Class: It is an orally active neurosteroid classified as a positive allosteric modulator of GAB_А receptors.

Synonyms: SAGE-217 and BIIB125.